Calcium leakage is the prime cause for muscle fatigue in the human body.
Athletes and bodybuilders who do high intensity workouts cause tiny amounts of calcium to leak.
The calcium, which helps the muscles contract, causes muscle fatigue when contraction of muscles becomes slow after a long and strenuous workout.
Lactic acid also gets accumulated in the muscles after a long workout.
Rest is the best remedy for muscle fatigue.
You should sleep for eight hours in a day to have a fresh body and mind.
A properly balanced nutritious diet is also essential for keeping the muscles in shape.
You should drink at least two litres of water daily in order to keep your body hydrated.
Cross training exercises have been known to enhance endurance levels and improve overall physical well being.
Cross training rejuvenates your body, soul and mind.
Top reasons for muscle fatigue

• Overworking your muscles causes the production of lactic acid which causes muscle tiredness.
  Always keep track of your limits while performing highly intense workouts like weight training and sprinting so that you can protect your body from any injuries.
  Rest between sets prevents tiredness from setting in.
  
• Insufficient periods of rest can increase muscle fatigue.
  Never give up on your sleep for any reason.
  To stimulate recovery, build muscle and increase endurance sleep is extremely important.
  
• Always stick to your workout plan.
  Random training can wreak havoc on your body.
  On when you stick to your plan can you develop your muscles properly.
  Regularise your reps and sets to avoid muscle fatigue and excessive strain.
  

In order to minimise fatigue, you should incorporate protein supplements and nitric oxide in your diet.
Many supplements are available that can be used to get instant energy.
Endurance can be improved by the intake of nitric oxide.
It stimulates blood flow through the body.
This keeps the muscles hydrated and supplies them with sufficient oxygen.
This in turn facilitates muscle building.
Nitric oxide increases you mental focus and bolsters your immune system.
It protects you from diabetes, cancer and cardiac arrests.
Nitric oxide also works as an anti-aging agent.