The 2000s were a big decade for comedy, and these are the comedians who had the best decade of all -- the ones who really broke out in the 2000s.

There was no bigger stand-up success story in the 2000s than Dane Cook. Using MySpace to cultivate his own celebrity, Cook became the hit comic of the college crowd and was quickly selling millions of records and selling out stadiums. He's the biggest thing to happen to comedy in nearly two decades, and pretty much owned the 2000s.