Percutaneous Extracorporeal Life Support in Circulatory Failure
Baseline characteristics of the study population are presented in Table 1. All patients were characterized by a high rate of comorbidities and cardiovascular risk factors. The majority of patients were male (76%) and overweight (body mass index >25).
All patients survived for at least 30 days following elective Lifebridge use. Despite poor prognosis of patients in severe hemodynamic crisis, 49% of the patients were alive at 30 days after emergency Lifebridge use. Information on successful weaning from the device as well as survival after 7 and 30 days is provided in Table 2 and Figure 1. In addition, a Kaplan-Meier curve was constructed for the emergency setting (Figure 2).
(Enlarge Image)
Figure 1.
Flow chart of patients who have been treated with the Lifebridge system.
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Figure 2.
Kaplan-Meier curve indicating the clinical course of patients with emergency Lifebridge support.
Mean duration of circulatory support was 162 minutes (range, 20 minutes - 26 hours). Mean duration of support was 107 minutes (range, 20 minutes – 7 hours) in elective patients. Longer durations of Lifebridge use (mean duration time, 308 minutes) were observed in patients with acute circulatory crisis (range, 20 minutes – 26 hours).
Procedural complication rate was very low in the elective group; only 1 vascular injury was documented without need for surgical repair.
In the emergency group, multi-organ failure occurred in 5 patients. Bleeding at the site of Lifebridge insertion occurred in 2 patients in whom transfusion of erythrocytes was required. Of note, no signs of relevant hemolysis were observed in any patient.
Results
Study Population
Baseline characteristics of the study population are presented in Table 1. All patients were characterized by a high rate of comorbidities and cardiovascular risk factors. The majority of patients were male (76%) and overweight (body mass index >25).
Primary Study Endpoint
All patients survived for at least 30 days following elective Lifebridge use. Despite poor prognosis of patients in severe hemodynamic crisis, 49% of the patients were alive at 30 days after emergency Lifebridge use. Information on successful weaning from the device as well as survival after 7 and 30 days is provided in Table 2 and Figure 1. In addition, a Kaplan-Meier curve was constructed for the emergency setting (Figure 2).
(Enlarge Image)
Figure 1.
Flow chart of patients who have been treated with the Lifebridge system.
(Enlarge Image)
Figure 2.
Kaplan-Meier curve indicating the clinical course of patients with emergency Lifebridge support.
Procedural Results/Safety and Feasibility
Mean duration of circulatory support was 162 minutes (range, 20 minutes - 26 hours). Mean duration of support was 107 minutes (range, 20 minutes – 7 hours) in elective patients. Longer durations of Lifebridge use (mean duration time, 308 minutes) were observed in patients with acute circulatory crisis (range, 20 minutes – 26 hours).
Procedural complication rate was very low in the elective group; only 1 vascular injury was documented without need for surgical repair.
In the emergency group, multi-organ failure occurred in 5 patients. Bleeding at the site of Lifebridge insertion occurred in 2 patients in whom transfusion of erythrocytes was required. Of note, no signs of relevant hemolysis were observed in any patient.
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