Neck Circumference and Early Stage Atherosclerosis
Neck circumference (NC) was recently associated with various cardiovascular risk factors such as insulin resistance and biochemical components of metabolic syndrome such as fasting glucose, fasting triglycerides, and blood pressure, independent of body mass index (BMI) and waist circumference. However, few studies have assessed the relation between NC and early stage atherosclerosis in Chinese adults.
Aortic stiffness is an established marker for early stage atherosclerosis. The recent European Society of Hypertension/European Society of Cardiology guidelines for management of arterial hypertension suggested measurement of pulse wave velocity (PWV) as a tool for assessment of subclinical atherosclerosis. PWV is a gold standard for assessing arterial stiffness, and has been widely used as an indicator for early-staged atherosclerosis. PWV measured at different sites may reflect the atherosclerotic alterations at central (e.g. carotid femoral pulse wave velocity (cfPWV)) or peripheral arteries (e.g. carotid artery dorsalis pedis pulse wave velocity (cdPWV) and carotid radial pulse wave velocity (crPWV)). cfPWV is recognized as the "gold standard" parameter for the evaluation of arterial stiffness and has had a wide biomedical application. The analysis of the peripheral pulse wave (cdPWV and crPWV) can provide parameters with different meanings in the arterial dynamics, some already used to assess the arterial stiffness.
The present study aimed to comprehensively investigate the relationship between NC and PWV measures for peripheral and central arterial stiffness in a large Chinese population.
Background
Neck circumference (NC) was recently associated with various cardiovascular risk factors such as insulin resistance and biochemical components of metabolic syndrome such as fasting glucose, fasting triglycerides, and blood pressure, independent of body mass index (BMI) and waist circumference. However, few studies have assessed the relation between NC and early stage atherosclerosis in Chinese adults.
Aortic stiffness is an established marker for early stage atherosclerosis. The recent European Society of Hypertension/European Society of Cardiology guidelines for management of arterial hypertension suggested measurement of pulse wave velocity (PWV) as a tool for assessment of subclinical atherosclerosis. PWV is a gold standard for assessing arterial stiffness, and has been widely used as an indicator for early-staged atherosclerosis. PWV measured at different sites may reflect the atherosclerotic alterations at central (e.g. carotid femoral pulse wave velocity (cfPWV)) or peripheral arteries (e.g. carotid artery dorsalis pedis pulse wave velocity (cdPWV) and carotid radial pulse wave velocity (crPWV)). cfPWV is recognized as the "gold standard" parameter for the evaluation of arterial stiffness and has had a wide biomedical application. The analysis of the peripheral pulse wave (cdPWV and crPWV) can provide parameters with different meanings in the arterial dynamics, some already used to assess the arterial stiffness.
The present study aimed to comprehensively investigate the relationship between NC and PWV measures for peripheral and central arterial stiffness in a large Chinese population.
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