Drug-induced Rheumatic Diseases
Purpose of review New drugs are continuously being developed and some rheumatic syndromes have been associated with specific drugs. As most of the rheumatic diseases are multisystem, it is worthwhile examining the wider case report literature to see whether any recent studies signify new associations between drugs and the rheumatic diseases. The last 2 years' case reports in English were scrutinized for noninfectious association with the rheumatic diseases. Cross-referencing from MEDLINE was performed using several databases including Google scholar; British Medical Journal (BMJ) case reports were also queried separately.
Recent findings Fifty-three articles comprising 56 case reports are included in the review, with 27 (48.2%) associated with the vasculitides, eight (14.3%) associated with lupus and 13 (23.2%) were associated with the myositis syndromes. The commonest four groups of drugs to potentially induce rheumatic diseases were anti-tumour necrosis factor (TNF) drugs, oncology drugs, propylthiouracil and interferons.
Summary It is important to recognise that drugs used in other specialties may induce rheumatic disease and vigilance on making a diagnosis is the key.
This review looks at published case reports published in the last 2 years and examines foremerging patterns for new drug-induced rheumatic diseases. Diseases included the common connective tissue diseases and inflammatory arthritides. Causality was implied from the publications and assumed - when there was more than one study in the literature implicating the disease as being caused by the agent.
Abstract and Introduction
Abstract
Purpose of review New drugs are continuously being developed and some rheumatic syndromes have been associated with specific drugs. As most of the rheumatic diseases are multisystem, it is worthwhile examining the wider case report literature to see whether any recent studies signify new associations between drugs and the rheumatic diseases. The last 2 years' case reports in English were scrutinized for noninfectious association with the rheumatic diseases. Cross-referencing from MEDLINE was performed using several databases including Google scholar; British Medical Journal (BMJ) case reports were also queried separately.
Recent findings Fifty-three articles comprising 56 case reports are included in the review, with 27 (48.2%) associated with the vasculitides, eight (14.3%) associated with lupus and 13 (23.2%) were associated with the myositis syndromes. The commonest four groups of drugs to potentially induce rheumatic diseases were anti-tumour necrosis factor (TNF) drugs, oncology drugs, propylthiouracil and interferons.
Summary It is important to recognise that drugs used in other specialties may induce rheumatic disease and vigilance on making a diagnosis is the key.
Introduction
This review looks at published case reports published in the last 2 years and examines foremerging patterns for new drug-induced rheumatic diseases. Diseases included the common connective tissue diseases and inflammatory arthritides. Causality was implied from the publications and assumed - when there was more than one study in the literature implicating the disease as being caused by the agent.
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