Dental Plaque Bacteria Susceptibility to Triclosan
Triclosan is a broad-spectrum antimicrobial agent developed over 40 years ago that is added to toothpaste to reduce dental plaque, gingivitis and oral malodor beyond that achieved using toothpastes without triclosan. Deasy et al. reported that compared to a fluoride dentifrice, a dentifrice containing 0.3% triclosan, 2% copolymer and 0.243% sodium fluoride reduced dental plaque by an additional 19% and reduced gingivitis by an additional 17% after three months of use, and by an additional 32% and 25%, respectively, after six months. Meta-analysis of sixteen clinical trials found that a 0.3% triclosan, 2% copolymer and 0.243% sodium fluoride dentifrice reduced dental plaque by 23%, gingival inflammation by 23% and gingival bleeding by 49% compared to a fluoride dentifrice. In addition to its efficacy in reducing dental plaque and gingivitis more than that achieved with a fluoride dentifrice, triclosan dentifrice has been reported to slow the progression of chronic periodontitis and to prevent recurrent periodontitis.
Several studies have examined the effects of the 0.3% triclosan, 2% copolymer and 0.243% sodium fluoride dentifrice on dental plaque bacteria and did not find the emergence of triclosan resistant bacteria in oral samples. A recently published study reported that triclosan-resistant bacteria did not develop after five years use of a triclosan-containing toothpaste. The present study examined supragingival dental plaque bacteria in samples collected over nineteen years for changes in susceptibility to triclosan.
Background
Triclosan is a broad-spectrum antimicrobial agent developed over 40 years ago that is added to toothpaste to reduce dental plaque, gingivitis and oral malodor beyond that achieved using toothpastes without triclosan. Deasy et al. reported that compared to a fluoride dentifrice, a dentifrice containing 0.3% triclosan, 2% copolymer and 0.243% sodium fluoride reduced dental plaque by an additional 19% and reduced gingivitis by an additional 17% after three months of use, and by an additional 32% and 25%, respectively, after six months. Meta-analysis of sixteen clinical trials found that a 0.3% triclosan, 2% copolymer and 0.243% sodium fluoride dentifrice reduced dental plaque by 23%, gingival inflammation by 23% and gingival bleeding by 49% compared to a fluoride dentifrice. In addition to its efficacy in reducing dental plaque and gingivitis more than that achieved with a fluoride dentifrice, triclosan dentifrice has been reported to slow the progression of chronic periodontitis and to prevent recurrent periodontitis.
Several studies have examined the effects of the 0.3% triclosan, 2% copolymer and 0.243% sodium fluoride dentifrice on dental plaque bacteria and did not find the emergence of triclosan resistant bacteria in oral samples. A recently published study reported that triclosan-resistant bacteria did not develop after five years use of a triclosan-containing toothpaste. The present study examined supragingival dental plaque bacteria in samples collected over nineteen years for changes in susceptibility to triclosan.
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