Advances in Drug Delivery to the Posterior Segment
Although intravitreal injections remain a mainstay of therapy for the management of posterior segment disease, particularly anti-VEGF agents for retinal vascular disease, intravitreal corticosteroid implants administered via office-based procedures or in the operating room offer a backdrop whereby sustained-release drug delivery has been developed. Approaches for the future of drug delivery include refillable surgical intravitreal implants, accessing the suprachoroidal space to take advantage of tissue targeting while limiting toxicity, and cell-based technologies to circumvent the need for repeated procedures.
Conclusion
Although intravitreal injections remain a mainstay of therapy for the management of posterior segment disease, particularly anti-VEGF agents for retinal vascular disease, intravitreal corticosteroid implants administered via office-based procedures or in the operating room offer a backdrop whereby sustained-release drug delivery has been developed. Approaches for the future of drug delivery include refillable surgical intravitreal implants, accessing the suprachoroidal space to take advantage of tissue targeting while limiting toxicity, and cell-based technologies to circumvent the need for repeated procedures.
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