Tiotropium in the Treatment of Patients With Asthma
We conducted a comprehensive search of MEDLINE and Embase databases, designed to capture relevant primary studies for inclusion in our review. The Fig. provides details of the search strategy used to obtain our results and is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search was performed in June 2012 and included all of the studies available on the topic. Verification searches were performed in September 2012 and October 2012.
(Enlarge Image)
Figure.
Search strategy of systematic review.
We used two main search terms—"asthma" and "tiotropium" as National Library of Medicine Medical Subject Headings—and used the Boolean operator "and" to combine the Medical Subject Headings terms. No other limits were used for search phrases. We performed a manual search of the references of captured articles and mined additional relevant articles for inclusion in the literature review. We used a three-tiered review process. Captured article titles first were screened by reviewers for study inclusion, followed by reviews of the title and abstract to identify articles for in-depth review by two independent reviewers. Selected articles were retrieved and two reviewers independently reviewed the full text.
We included studies that investigated the role of tiotropium in the management of adult patients with asthma. We also included studies of patients with variable disease severity and control and patients taking concomitant asthma medications. We excluded studies for which full-text English-language versions were not available for review and those lacking quantitate investigative methods such as case reports. Data were extracted from full-text articles and compiled independently by two authors. Discord was settled by discussion and further review.
Methods
We conducted a comprehensive search of MEDLINE and Embase databases, designed to capture relevant primary studies for inclusion in our review. The Fig. provides details of the search strategy used to obtain our results and is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search was performed in June 2012 and included all of the studies available on the topic. Verification searches were performed in September 2012 and October 2012.
(Enlarge Image)
Figure.
Search strategy of systematic review.
We used two main search terms—"asthma" and "tiotropium" as National Library of Medicine Medical Subject Headings—and used the Boolean operator "and" to combine the Medical Subject Headings terms. No other limits were used for search phrases. We performed a manual search of the references of captured articles and mined additional relevant articles for inclusion in the literature review. We used a three-tiered review process. Captured article titles first were screened by reviewers for study inclusion, followed by reviews of the title and abstract to identify articles for in-depth review by two independent reviewers. Selected articles were retrieved and two reviewers independently reviewed the full text.
We included studies that investigated the role of tiotropium in the management of adult patients with asthma. We also included studies of patients with variable disease severity and control and patients taking concomitant asthma medications. We excluded studies for which full-text English-language versions were not available for review and those lacking quantitate investigative methods such as case reports. Data were extracted from full-text articles and compiled independently by two authors. Discord was settled by discussion and further review.
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