History

• Lyrica was originally approved by the FDA to assist in managing diabetic peripheral neuropathy and post-herpetic neuralgia. The 2007 approval to expand Lyrica to treat fibromyalgia made the drug the first medicine to receive FDA approval to specifically treat that disease. Prior to this, fibromyalgia treatment involved a cafeteria style of management that included pain relievers, anti-depressants, and muscle relaxers.
  
  

Function

• The establishment of Lyrica's efficacy in treating fibromyalgia was the result of two successful clinical studies. The studies utilized a random, double-blind approach using a placebo as the control medication. The result of these studies indicated that a dose between of either 300 mg or 450 mg a day could improve reduce pain and improve patient function. The results were confirmed when patients showed a marked relapse when they stopped receiving their daily dosage of Lyrica.
  
  

Benefits

• Lyrica achieves these results by soothing the damaged nerves that create pain. In particular, Lyrica is effective at reducing the specific kind of sharp burning pain experienced by patients suffering from diseases like shingles and fibromyalgia, as well as those who suffer from diabetic nerve pain.
  
  

Theories/Speculation

• An exact explanation for how Lyrica works has yet to be identified. Studies using animals have led researchers to speculate that Lyrica works by somehow reducing the number of electrical charges produced by the nerves that have been damaged. Other studies suggest that the medication actually affects how the brain allows patients to experience pain.
  
  

Effects

• The side effects of Lyrica include such things as dizziness, dry mouth, blurred vision, weight gain, constipation, heightened sensitivity, swelling, and difficulty concentrating. As with all medications, the side effects that any individual experiences will vary, including the possibility that a person may experience no negative effects at all. Consult with a doctor before taking Lyrica.
  
  

Warning

• Lyrica may interact with other drugs. Among those listed as having the greatest potential for interaction are alcohol, antihistamines, barbituates, certain drugs to treat diabetes (including Avandia and Actos) , medications that treat Parkinson's (including Stalevo and Tasmar), certain relaxation or sleep aids such as Xanax and Valium, and tricyclic antidepressants. When consulting with a physician about the possibility of taking Lyrica, be sure to mention all other medications you are currently taking.
  
  

Considerations

• Lyrica should be taken only at the prescribed dosage. If you forget to take the medication, take it immediately unless it is nearly time for a second dose, in which case you should only take one dose. Never combine dosages, but instead take them at the time intervals indicated on the label. Even if you begin feeling relief from the pain, take the next dose on schedule. Always consult with your physician before deciding to stop taking Lyrica.